Product ID:PROTEASE TYPE XXI FROM STREPTOMYCES GRISEUS, P0652
MSDS Date:01/01/1999
FSC:6810
NIIN:00N092702
Status Code:A
MSDS Number: CJTQB

Emergency Phone: 314-771-5765

Info Phone: 314-771-5765

Cage: 21076

Telephone: 314-771-5765

Cage: 21076

PROTEASE TYPE XXI FROM STREPTOMYCES GRISEUS

LD50 LC50 Mixture:LD50 (ORAL, RAT): 3290 MG/KG
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE: HARMFUL IF INHALED. MAY BE
HARMFUL IF SWALLOWED. MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN.
CAUSES IRRITATION. MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND
UPPER RESPIRATORY TRACT. MAY CAUS E ALLERGIC RESPIRATORY AND SKIN
REACTIONS. REPEATED EXPOSURE CAN CAUSE: ASTHMA. TARGET ORGAN (S):
LUNGS.
Effects of Overexposure:SEE HEALTH HAZARDS.

First Aid:IINGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS
CONSCIOUS. CALL A PHYSICIAN. SKIN: FLUSH WITH COPIOUS AMOUNTS OF
WATER FOR AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND
SHOES. CALL A PHYSICIAN. INHALATION: REMOVE TO FRESH AIR. IF
BREATHING BECOMES DIFFICULT, CALL A PHYSICIAN. EYES: FLUSH WITH
COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE
FLUSHING BY SEPARATING THE EYELIDS WITH FINGER. CALL A PHYSICIAN.

Extinguishing Media:WAATER SPRAY, CARBON DIOXIDE, DRY CHEMICAL POWER OR
APPRORIATE FOAM.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA & FULL PROTECTIVE
EQUIPMENT .

Spill Release Procedures:WEAR SELF-CONTAINED BREATHING APPARATUS,
RUBBER BOOTS AND HEAVY RUBBER GLOVES. SWEEP UP, PLACE IN A BAG AND
HOLD OR WASTE DISPOSAL. AVOID RAISING DUST. VENTILATE AREA AND WASH
SPILL SITE AFTER MATERIA L PICKUP IS COMPLETE.

Handling and Storage Precautions:HANDLE IN A CLOSED SYSTEM.

Respiratory Protection:WEAR APPROPRATE NIOSH-APPROVED RESPIRATOR.
Ventilation:USE ONLY IN A CHEMICAL FUME HOOD.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:EYE WASH AND DELUGE SHOWER MEETING ANSI
DESIGN CRITERIA . OTHER PROTECTIVE CLOTHING.
Supplemental Safety and Health

Appearance and Odor:SOLID.

Stability Indicator/Materials to Avoid:YES
Hazardous Decomposition Products:NATURE OF DECOMPOSITON PRODUCTS NOT
KNOWN.
Conditions to Avoid Polymerization:WILL NOT OCCUR.

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
ENVIRONMENTAL REGULATIONS.

Toxicological Information:THE TOXICOLOGICAL PROPERTIES HAVE NOT BEEN
THOROUGHLY INVESTIGATED. MAY BE MORE POTENT AND BROADER IN
SPECIFICITY THAN OTHER PROTEASES. RTECS #: UK9595000. PROTEINASE,
STREPTOMYCES GRISEUS. TOXICITY D ATA: ORL-RAT LD50:3290 MG/KG
NIIRDN 6,730,1982. IPR-RAT LD50:16200 UG/KG NIIRDN 6,730,1982.
SCU-RAT LD50:100 MG/KG NIIRDN 6,730,1982. IVN-RAT LD50:15800 UG/KG
NIIRDN 6,730,1982. ORL-MUS LD50:4010 MG/K G NIIRDN 6,730,1982.
IPR-MUS LD50:14100 UG/KG NIIRDN 6,730, 1982. SCU-MUS LD50:26800
UG/KG NIIRDN 6,730,1982. IVN-MUS LD50:20500 UG/KG NIIRDN
6,730,1982. ORL-RBT LD50:1243 KU/KG IYKEDH 26,364,1995 (OT HER
INFO)

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:DATA NOT YET AVAILABLE.

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
INFORMATION.

Federal Regulatory Information:EUROPEAN INFORMATION: HARMFUL R 20
HARMFUL BY INHALATION. R 42/43 MAY CAUSE SENSITIZATION BY
INHALATION AND SKIN CONTACT. R 36/37/38 IRRITATING TO EYES,
RESPIRATORY SYSTEM AND SKIN. S 26 IN CASE OF CO NTACT WITH EYES,
RINSE IMMEDIATELY WITH PLENTY OF WATER AND SEEK MEDICAL ADVICE. S
36 WEAR SUITABLE PROTECTIVE CLOTHING. S 22 DO NOT BREATHE DUST.